Chondrosarcoma- Features and Treatment

Chondrosarcoma is a tumor of adults. It rarely is encountered in the adolescent and almost never in a child.
There are four different types of chondrosarcoma

  • Primary
  • Secondary
  • Mesenchymal
  • Dedifferentiated.

The great majority of cases are primary or secondary chondrosarcoma. The mesenchymal and dedifferentiated types are extremely rare. [Read more...]

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Osteogenic Sarcoma-Treatment

First approach to treatment of osteogenic sarcoma is making a definitive diagnosis. After diagnosis has been established, patient should be put on preoperative adjuvant chemotherapy.

This should continue for four to six weeks. Advantgages of preoperative adjuvant chemotherapy are

  • It reduces edema and decreases the size of the primary tumor thus making limb salvage surgery feasible
  • It helps to determine the response of the primary tumor to a specific chemotherapeutic agents.

Early administration of chemotherapeutic agents,will destroy occult micrometastases and occult microextensions and will improve the overall prognosis.

After preoperative adjuvant chemotherapy, the next step is is definitive surgery followed by additional adjuvant chemotherapy for 12 months.

Tumor cell destruction as shown by histologic examination of the resected primary tumor helps in deciding chemotherapeutic agents. [Read more...]

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Osteogenic Sarcoma- Staging and Biopsy

Osteogenic sarcoma is treated by radical excision and adjuvant chemotherapy. Before one proceeds for treatment, the clinical and radiographic diagnosis should always be confirmed by histologic examination of adequate tissue obtained by open biopsy.

Exuberant callus of a stress fracture, subacute osteomyelitis, active myositis ossificans, aneurysmal bone cyst, and eosinophilic granuloma are some of the benign conditions that can easily be mistaken for osteogenic sarcoma. Ewing’s sarcoma, fibrosarcoma, and metatastic carcinoma are some of the malignant lesions that must be considered in the differential diagnosis. [Read more...]

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Osteogenic Sarcoma-Radiographic and Labortary Findings

Osteogenic sarcoma presents a typical radiographic picture of destructive and osteoblastic changes.

The neoplasm usually begins eccentrically in the metaphyseal region of a long bone.

Bone destruction manifests itself as a loss of normal trabecular pattern and the appearance of irregular ill-defined, poorly marginated, ragged radiolucent defects.

New bone formation may be neoplastic or reactive and appears in the form of areas of increased radiopacity. [Read more...]

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Osteogenic Sarcoma-Clinical Presentation

Osteogenic sarcoma develops from cells of the mesenchymal series, which form neoplastic osteoid and osseous tissue either directly or indirectly by rapid growth of development.

The classic osteogenic sarcoma develops in the interior of a bone. Juxta-cortical osteogenic sarcoma develops in relation to the periosteum and immediate parosteal connective tissue. It is less common, but has a much better prognosis. Endosteal osteo-sarcoma is a variant of parosteal osteosarcoma that arises within bone from the endosteum, a low-grade malignant tumor that grows slowly and metastasizes late. [Read more...]

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Cellular and Biochemical Changes of Lumbar Spondylosis

Lumbar degeneration or spondylosis is can be seen on the biochemical, cellular, and morphologic levels. The initial events of disc degeneration are related to many intrinsic and extrinsic factors, including cellular apoptosis or programmed cell death, mechanical disc injury, and genetic contributions.

The culprit event likely is related to compromise nutrient diffusion and disc hydration. [Read more...]

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Morphologic and Biomechanical Changes In Lumbar Spondylosis

Three clinical and biomechanical stages of spinal degeneration have been described

  • Initial early changes with mild dysfunction but no instability
  • Later degenerative instability
  • Disk space collapse. [Read more...]

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Biology of the Intervertebral Disc

Chondrocytes and fibroblastic cells are tissue constituents in the anulus, nucleus, and end plates. All these are are within an extensive, intricate extracellular matrix (ECM).

These cells are responsible for homeostasis of the ECM, including matrix formation, maintenance, and remodeling. The nutrition to these cells is derived from diffusion across the hyaline cartilage and subcortical end plates. [Read more...]

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Nerve Injuries In Acetabular Fractures

Nerve Injuries are quite common in acetabular fractures. Most common nerve involved is sciatic nerve. Incidence of injury to other nerves is quite less.

It is pertinent that every case of acetabular fractures should be evaluated for nerve injuries so that such injuries are not missed. [Read more...]

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