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Articles on arthritis and related joint disorders

Orthotics May Relieve Pain Around Ankle and Foot In Rheumatoid Arthritis

January 15, 2012 By Leave a Comment

Though weak, there is an evidence to show that custom orthotics may help relieve pain and elevated forefoot plantar pressures in patients with rheumatoid arthritis

This has been reported by a meta-anlysis conducted by Kym Hennessy and colleagues at Glasgow Caledonian University and published online December 12 in Arthritis Care & Research

The study involved analysis of 17 studies involving more than 700 patients. According to researchers, most of the studies they analyzed were not of high quality.
[Read more...]

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What Are Risk Factors for Osteoarthritis

April 24, 2011 By Leave a Comment

Osteoarthritis is also called called degenerative joint disease or osteoarthroses occurs when cartilage in the joints wears down over time.

It can affect any joint in your body. But most commonly it is seen in following joints

  • Hips
  • Knees
  • Hands
  • Spine [also called spondylosis]

Following are the risk factors for this disease [Read more...]

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Magnetic Resonance Imaging Identifies Early Stage Rheumatoid Arhtritis Better Than Clinical Examination

December 21, 2010 By Leave a Comment

Magnetic resonance imaging  is very sensitive and identifies joint damage in the wrists and fingers of patients with early-stage rheumatoid arthritis, a new research published on November 15th in Arthritis Care & Research.

The study was conducted by Dr. Mami Tama and colleagues in Nagasaki University.
In the study, MRI of wrists and finger joints of both hands were examined in 51 early-stage rheumatoid arthritis (RA) patients by both plain and Gd-DTPA enhanced MRI.

Synovitis, bone edema and bone erosion were considered as MRI-proven joint injury. A physical examination just before the MRI study was done by certified rheumatologist.

The presence of tender and/or swollen joints in the same fields as MRI was considered as joint injury on physical examination.
The association of MRI-proven joint injury with physical examination-proven joint injury was examined.

A total of 1110 sites were examined in the above mentioned patients.

MRI-proven joint injury was found in 521 sites whereas other 589 sites were normal.
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Smoking Causes Greater Risk For Rheumatoid Arthrits

December 13, 2010 By 1 Comment

Cigarette smoking is linked to a greater risk for rheumatoid arthritis  in African Americans, according to the results of a study reported in the December issue of Arthritis & Rheumatism.

The study cohort consisted of 605 African American patients with rheumatoid arthritis and 255 healthy control participants to evaluate the associations of cigarette smoking with rheumatoid arthritis in African Americans and to examine the effect of the HLA-DRB1 shared epitope  on this association

An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells

Participants were evaluated  to determine associations of smoking with RA and additive and multiplicative shared epitope  smoking interactions. [Read more...]

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Anakinra Is Found To Be Effective In Muckle Wells Syndrome

December 11, 2010 By 1 Comment

Anakinra is  recombinant interleukin (IL)-1 receptor antagonist.  A new study published in  Arthritis & Rheumatism online has found that anakinra is safe and effective for severe Muckle-Wells syndrome.

The researchers investigated the efficacy of anakinra in 12 patients with severe Muckle Wells syndrome. Seven patients were adults and five were children.

All constitutional symptoms resolved by 2 weeks, and there was near complete resolution of musculoskeletal manifestations and significant improvement in ocular symptoms and skin manifestations. [Read more...]

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What Is Muckle Wells Syndrome?

December 10, 2010 By 1 Comment

Muckle-Wells syndrome [Also known by the names of  UDA (Urticaria Deafness Amyloidosis) syndrome   is a rare autosomal dominant disease which results in

  • Sensorineural deafness
  • Recurrent hives
  • Amyloidosis - A disease where abnormal deposition of amyloid occurs in various organs.
  • Fevers
  • Painful joints (arthritis)

MWS was first described in 1962 by Thomas James Muckle and Michael Vernon Wells. It is rare disorder and exact incidence is not known. [Read more...]

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Tocilizumab Inhibits Joint Damage In Rheumatoid Arthritis Not Adequately Controlled With Methotrexate

December 8, 2010 By Leave a Comment

Tocilizumab is the IL-6 receptor-blocking monoclonal antibody. In new data published in Arthritis and Rheumatism, it has been reported that tocilizumab inhibits joint damage in patients with rheumatoid arthritis that’s not adequately controlled with methotrexate.

Tocilizumab was approved in January this year for use in treatment of moderate to severe active rheumatoid arthritis.

The present trial involved 1196 patients with inadequate responses to methotrexate. [Read more...]

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A Simple Classification Of Osteoarthritis

November 28, 2010 By Leave a Comment

PRIMARY Or IDIOPATHIC
Peripheral joints
Spine

  • Apophyseal joints
  • Intervertebral joints

Subsets

  • Generalized osteoarthritis
  • Erosive inflammatory osteoarthritis
  • Diffuse idiopathic skeletal hyperostosis
  • Chondromalacia patellae

Hereditary [Read more...]

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Patients Of Osteoarthritis Knee With Pain In Other Joints Have Greater knee Pain

November 27, 2010 By Leave a Comment

A new study published in Arthritis Care & Research,  December 2010 print issue reports that those patients with knee osteoarthritis who have pain in other joints as well are more likely to experience greater pain in the knee.

The  lower back, foot, and elbow pain on the same side as the affected knee were associated with more severe knee pain.

The researchers analyzed data from the Osteoarthritis Initiative, a database including 1389 individuals aged 45 to 79 years with symptomatic tibiofemoral knee OA. [Read more...]

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Drugs For Rheumatoid Arthritis Less Effective In Obese Patients

November 20, 2010 By Leave a Comment

A small study has suggested that obese adults with rheumatoid arthritis may be less likely than thinner people to respond to some of the newer medications for the disease.

The study included 89 patients who were put on infiximab and it was found that found obese patients improved less than leaner ones.

The study has been published in online November 8th in Arthritis & Rheumatism,

It is not clear why does this occur but  adipocytokines — inflammation-promoting proteins produced by fat tissue  are thought to play a role.

This may send an alert to the physicians that TNF blockers might be relatively less effective in obese people.

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