Etanercept May Help Restore Normal Growth In Children With Juvenile Idiopathic Arthritis

According to a recent study conducted bu Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, and published in November 2010 issue of Arthritis & Rheumatism, the drug Etanercept with or without methotrexate may help restore normal growth in children with juvenile idiopathic arthritis (JIA).

Methotrexate alone was not found effective in this aspect. [Read more...]

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New Method Developed For MRI To Detect Early Osteoarthritis In Knee

A research conducted by New York University have developed a method to use MRI to examine sodium ions in cartilage and view the development of osteoarthritis in knee joints.

This may provide a noninvasive method to diagnose osteoarthritis in its very early stages. It would also help to calculate measures of cartilage assessments.

The measurement reveal the location of glycosaminoglycans  in cartilage tissues. Glycosaminoglycans serve as the building blocks of cartilage  apart from other functions in the human body. [Read more...]

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Varus Knees Have An Increased Risk For Development Of Osteoarthritis

A study published in the Annals of the Rheumatic Diseases has suggested that people with varus knee alignment have an increased risk for the development of osteoarthritis of the knee.

The aim of this study was to test whether alignment influences the risk for the development of new OA and to determine whether varus and valgus alignment cause the condition to progress in existing osteoarthritis.

Varus and valgus alignment increase, respectively, medial and lateral tibiofemoral load, the authors observed.

The study included 2713 volunteers aged 50 to 79 years. All had arthritis or were at increased risk for the development of the condition because they were overweight, had knee surgery, or had a previous knee injury.

The study carried full-limb x-rays from the hip to the knee to the ankle and knee x-rays at the beginning entry and at 30 months. [Read more...]

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Xray of Bilateral Hands In Rheumatoid Arthritis Showing Dislocation of All Metacarpophalangeal Joints

Untreated rheumatoid arthritis can lead to severe deformities. Following xrays are of a 43 years old woman who was a known case of rheumatoid arthritis and had taken on and off treatment.

She presented with deformed hands and pain in bilateral hips. The problem had persisted  for past 10 years.

hand-deformed-rheumatoid arthritis

Bilateral Deformed Hands In Rheumatoid Arthritis

The xrays of the hip revealed bilateral arthritic changes. [Read more...]

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Anteroposterior Xray Of Both Knees Showing Severe Osteoarthritis, Varus Deformity and Subluxation

This xray belongs to 58 year old women who weighed 120 khs and had severe pain in both the knees for last 10 years. patient was unable to walk beyond 10 steps even with support.
She also had respiratory and cardiac ailments.
The xray in picture shows severely destroyed knees with varus deformity in both sides along with subluxation of the knee joints on both sides.

The patient had been advised total knee replacement [TKR] two years back but she refused. This time she had come with a request to get operated for total knee replacement but her physician told her about the risk involved due to her medical illness.

The patient again refused.

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What Is Chondrocalcinosis?

Chondrocalcinosis is another name for Calcium pyrophosphate dihydrate disease, a rheumatologic disorder with varied clinical manifestations due to precipitation of calcium pyrophosphate dihydrate crystals in the connective tissues.

Its alternative names specify clinical or radiographic findings.

Pseudogout refers to the clinically evident acute synovitis with red, tender, and swollen joints that may resemble arthritis of gout.chondrocalcinosis

Chondrocalcinosis, refers to the radiographic evidence of calcification in hyaline and/or fibrocartilage.
It is also called Pyrophosphate arthropathy. The knee joint is the most commonly affected.

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What Are Bone Spurs or Osteophytes

A bone spur is a bony growth formed on normal bone. In medical language, it is termed as osteophyte. A bone spur is an extra bone and can cause symptoms due to pressure on adjacent tissues.

Spurs can be commonly found in

  • Spine
  • Shoulder
  • Hand
  • Hip
  • Knee
  • Foot.

How Does A Spur Form?

A bone spur is response by the body to some sort of external stimulus. This  repair  response may lead to formation of extra bone called spur. [Read more...]

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Avascular Necrosis Bilateral Head of Femur With Arthritic Changes – Xray

Avascular necrosis (AVN) of head of femur occurs when blood supply to the head is jeopardized. That may occur when blood vessels are injured or the pressure within the bone rises enough to cause narrowing of blood vessels resulting in ischaemia of the bone.

The various known causes of avascular necrosis of hip are

  • Trauma
  • Prolonged steroid use
  • Excessive alcohol use
  • Gaucher’s disease
  • Pancreatitis
  • Radiation treatments and chemotherapy

There are percentage of people in whom the cause cannot be determined and are labeled as idiopathic AVN.

avascular-necrosis-bilateral-head-femur

[Read more...]

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Xray of Bilateral Medial Compartment Osteoarthritis of knee

Osteoarthritis of knee is very common problem in Asian region. The disease typically starts in medial compartment of the knee and then progresses to all the compartments.

OA bilateral knee

OA bilateral knee

The xray belongs to a lady of 49 years old whose main complaint was pain on climbing stairs. An xray doen revealed bilateral medial compartment involvement.

The patient is being managed on conservative treatment.

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Osteoarthritis – Structure of Articular Cartilage

Cartilage is the layer covering a joint. Its main function is to produce smooth articulations among the joint surfaces. Type of cartilage in synovial  joint is hyaline cartilage. Hyaline cartilage is a hard, translucent material rich in Type II collagen and proteoglycan.

To reduce the friction, the cartilage is lubricated by various mechanisms.

Synovial  joints serve as mechanical bearings with  low coefficients of friction. Their three major sources of lubrication are:

Hydrodynamic lubrication

Loading of the articular cartilage causes compression that forces water out of the cartilage. This fluid forms an aqueous layer that separates and protects the opposing surfaces.

Boundary layer lubrication

A small glycoprotein called lubricin, which is produced by synovial lining cells, binds to articular cartilage where it retains a protective layer of water molecules.

Hyaluronic acid

It i s produced by synovial lining cells and lubricates the contact surface between synovium and cartilage. [Read more...]

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