Orthopedic Care and Consultation
According to dietary guidelines published online April 29 in Pediatrics, Vitamin D supplementation is recommended for preterm infants both while they are still in the hospital and after discharge.
The guidelines, the first dietary recommendations for vitamin D and calcium intakes specifically designed for preterm infants have been developed by Steven A. Abrams along with the American Academy of Pediatrics Committee on Nutrition.
[Read more...]
Boston University School of Medicine researchers have reported that have discovered that eating mushrooms containing Vitamin D2 is effective at increasing and maintaining vitamin D levels as taking supplemental vitamin D2 or vitamin D3.
These findings will be presented at the American Society for Biochemistry and Microbiology annual meeting in Boston on April 22 and also concurrently appear in Dermato-Endocrinology on line open access.
Vitamin D is crucial for good bone health and muscle strength and adequate amounts help to
The present study consisted of 30 healthy adults who were randomized to take capsules containing 2000 International Units (IU) of vitamin D2, 2000 IU of vitamin D3 or 2000 IU of mushroom powder containing vitamin D2 once a day for 12 weeks during the winter.
After 12 weeks of the vitamin D supplements, serum vitamin D levels were not statistically significantly different than those who ingested 2000 IU of vitamin D2 in mushroom powder.
The authors suggested that ingesting mushrooms exposed to ultraviolet light are a good source of vitamin D and are as effective in raising and maintaining a healthy adult’s vitamin D status as ingesting a supplement that contained either vitamin D2 or vitamin D3,
According to the researchers these abstracts as well as the on line published study demonstrate that mushrooms are another good natural food source for vitamin D that can easily be found in ones’ local grocery store.
Sources
The nonsteroidal anti-inflammatory drug diclofenac has been found to be associated with an increased risk of cardiovascular complications.
This has been reported by a study authored by Patricia McGettigan and David Henry, published in journal PLOS Medicine on Feb 12 2013.
Diclofenacis listed on the essential medicine list of 74 countries.
The authors have reported a risk similar to that by rofecoxib, a drug withdrawn from worldwide markets because of cardiovascular toxicity. [Read more...]
Vitamin D, essential for skeletal health in developing children. Vitamin D deficiency is common in overweight and obese children, especially in severely obese and minority children in US, according to a new study.
The study by Turer and colleagues has been published on December 24 in Pediatrics in online early releases.
The current study determined the prevalence of vitamin D deficiency in 12992 children between ages 6- to 18-year, enrolled in the 2003 to 2006 National Health and Nutrition Examination Survey.
Vitamin D deficiency was defined as 25-hydroxyvitamin-D levels lower than 20 ng/mL. [Read more...]
Cabozantinib is a small molecule inhibitor of the tyrosine kinases c-Met and Vascular endothelial growth factor receptor-2 (VEGFR2).
[C-Met is a proto-oncogene that encodes a protein known as hepatocyte growth factor receptor which possesses tyrosine-kinase activity. A proto-oncogene is a normal gene that can become an oncogene due to mutations or increased expression. Proto-oncogenes code for proteins that help to regulate cell growth and differentiation]
Cabozantinib has been shown to reduce tumor growth, metastasis, and angiogenesis.
It was formerly known as XL184.
It was developed by Exelixis Inc and is marketed under trade name Cometriq. [Read more...]
Oral bisphosphonate alendronate does noot reduce the incidence of fractures in children with osteogenesis imperfecta. This has been suggested by findings findings published November 24th online in The Journal of Clinical Endocrinology & Metabolism.
With an objective to study the efficacy and safety of daily oral alendronate in children with osteogenesis imperfecta, Dr Ward et al conducted a multicenter, double-blind, randomized, placebo-controlled study.
The study included 139 children between 4–19 years of age having with type I, III, or IV osteogenesis imperfecta. [Read more...]
A small study has suggested that obese adults with rheumatoid arthritis may be less likely than thinner people to respond to some of the newer medications for the disease.
The study included 89 patients who were put on infiximab and it was found that found obese patients improved less than leaner ones.
The study has been published in online November 8th in Arthritis & Rheumatism,
It is not clear why does this occur but adipocytokines — inflammation-promoting proteins produced by fat tissue are thought to play a role.
This may send an alert to the physicians that TNF blockers might be relatively less effective in obese people.
The US Food and Drug Administration has approved drug denosumab for use to prevention of to prevent skeletal complications in cancer patients with solid tumors and bone metastases.
The drug has already been approved and in market for postmenopausal osteoporosis.
The drug is used in different doses in in these two conditions. [Read more...]
The United States Food and Drug Administration has approved duloxetine HCl delayed-release capsules for treatment of chronic musculoskeletal pain.
That gives many of the chronic pain patients another treatment option.
Duloxetine has been approved for both chronic low back pain and osteoarthritis. The decision was based on data from 4 double-blind, randomized clinical trials.
The recommended dose is 60 mg daily. [Read more...]
A systematic review study published in Cochrane Database of Systematic Reviews has revealed that use supplements of vitamin D, is not consistent with improvement of bone density in children with normal vitamin D levels. However a definite benefit in vitamin D deficient children was observed. [Read more...]
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