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Smoking Causes Greater Risk For Rheumatoid Arthrits

December 13, 2010 By 1 Comment

Cigarette smoking is linked to a greater risk for rheumatoid arthritis  in African Americans, according to the results of a study reported in the December issue of Arthritis & Rheumatism.

The study cohort consisted of 605 African American patients with rheumatoid arthritis and 255 healthy control participants to evaluate the associations of cigarette smoking with rheumatoid arthritis in African Americans and to examine the effect of the HLA-DRB1 shared epitope  on this association

An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells

Participants were evaluated  to determine associations of smoking with RA and additive and multiplicative shared epitope  smoking interactions. [Read more...]

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Anakinra Is Found To Be Effective In Muckle Wells Syndrome

December 11, 2010 By 1 Comment

Anakinra is  recombinant interleukin (IL)-1 receptor antagonist.  A new study published in  Arthritis & Rheumatism online has found that anakinra is safe and effective for severe Muckle-Wells syndrome.

The researchers investigated the efficacy of anakinra in 12 patients with severe Muckle Wells syndrome. Seven patients were adults and five were children.

All constitutional symptoms resolved by 2 weeks, and there was near complete resolution of musculoskeletal manifestations and significant improvement in ocular symptoms and skin manifestations. [Read more...]

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What Is Muckle Wells Syndrome?

December 10, 2010 By 1 Comment

Muckle-Wells syndrome [Also known by the names of  UDA (Urticaria Deafness Amyloidosis) syndrome   is a rare autosomal dominant disease which results in

  • Sensorineural deafness
  • Recurrent hives
  • Amyloidosis - A disease where abnormal deposition of amyloid occurs in various organs.
  • Fevers
  • Painful joints (arthritis)

MWS was first described in 1962 by Thomas James Muckle and Michael Vernon Wells. It is rare disorder and exact incidence is not known. [Read more...]

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Tocilizumab Inhibits Joint Damage In Rheumatoid Arthritis Not Adequately Controlled With Methotrexate

December 8, 2010 By Leave a Comment

Tocilizumab is the IL-6 receptor-blocking monoclonal antibody. In new data published in Arthritis and Rheumatism, it has been reported that tocilizumab inhibits joint damage in patients with rheumatoid arthritis that’s not adequately controlled with methotrexate.

Tocilizumab was approved in January this year for use in treatment of moderate to severe active rheumatoid arthritis.

The present trial involved 1196 patients with inadequate responses to methotrexate. [Read more...]

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A Simple Classification Of Osteoarthritis

November 28, 2010 By Leave a Comment

PRIMARY Or IDIOPATHIC
Peripheral joints
Spine

  • Apophyseal joints
  • Intervertebral joints

Subsets

  • Generalized osteoarthritis
  • Erosive inflammatory osteoarthritis
  • Diffuse idiopathic skeletal hyperostosis
  • Chondromalacia patellae

Hereditary [Read more...]

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Patients Of Osteoarthritis Knee With Pain In Other Joints Have Greater knee Pain

November 27, 2010 By Leave a Comment

A new study published in Arthritis Care & Research,  December 2010 print issue reports that those patients with knee osteoarthritis who have pain in other joints as well are more likely to experience greater pain in the knee.

The  lower back, foot, and elbow pain on the same side as the affected knee were associated with more severe knee pain.

The researchers analyzed data from the Osteoarthritis Initiative, a database including 1389 individuals aged 45 to 79 years with symptomatic tibiofemoral knee OA. [Read more...]

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Drugs For Rheumatoid Arthritis Less Effective In Obese Patients

November 20, 2010 By Leave a Comment

A small study has suggested that obese adults with rheumatoid arthritis may be less likely than thinner people to respond to some of the newer medications for the disease.

The study included 89 patients who were put on infiximab and it was found that found obese patients improved less than leaner ones.

The study has been published in online November 8th in Arthritis & Rheumatism,

It is not clear why does this occur but  adipocytokines — inflammation-promoting proteins produced by fat tissue  are thought to play a role.

This may send an alert to the physicians that TNF blockers might be relatively less effective in obese people.

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Etanercept May Help Restore Normal Growth In Children With Juvenile Idiopathic Arthritis

November 14, 2010 By Leave a Comment

According to a recent study conducted bu Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, and published in November 2010 issue of Arthritis & Rheumatism, the drug Etanercept with or without methotrexate may help restore normal growth in children with juvenile idiopathic arthritis (JIA).

Methotrexate alone was not found effective in this aspect. [Read more...]

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New Method Developed For MRI To Detect Early Osteoarthritis In Knee

September 24, 2010 By Leave a Comment

A research conducted by New York University have developed a method to use MRI to examine sodium ions in cartilage and view the development of osteoarthritis in knee joints.

This may provide a noninvasive method to diagnose osteoarthritis in its very early stages. It would also help to calculate measures of cartilage assessments.

The measurement reveal the location of glycosaminoglycans  in cartilage tissues. Glycosaminoglycans serve as the building blocks of cartilage  apart from other functions in the human body. [Read more...]

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Varus Knees Have An Increased Risk For Development Of Osteoarthritis

September 8, 2010 By Leave a Comment

A study published in the Annals of the Rheumatic Diseases has suggested that people with varus knee alignment have an increased risk for the development of osteoarthritis of the knee.

The aim of this study was to test whether alignment influences the risk for the development of new OA and to determine whether varus and valgus alignment cause the condition to progress in existing osteoarthritis.

Varus and valgus alignment increase, respectively, medial and lateral tibiofemoral load, the authors observed.

The study included 2713 volunteers aged 50 to 79 years. All had arthritis or were at increased risk for the development of the condition because they were overweight, had knee surgery, or had a previous knee injury.

The study carried full-limb x-rays from the hip to the knee to the ankle and knee x-rays at the beginning entry and at 30 months. [Read more...]

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