Aneurysmal Bone Cyst In Neck Of Femur – Xray

Following xray is of a cystic lesion in neck of femur in 11 years old male child which was later dignosed as aneurysmal bone cyst.

Aneurysmal Bone Cyst In Neck Of Femur - Xray

Aneurysmal Bone Cyst In Neck Of Femur – Xray

No other associated information could be found for thr file. Note the multiple septae in the lesion which is one of the features of aneurysmal bone cyst.

What is Osteopoikilosis?

Osteopoikilosis is a  benign, autosomal dominant skeletal dysplasia that  manifests radiographically as multiple bone islands which are especially seen near the joints, epiphyses, metaphyses of long and short tubular bones.

The islands are also seen in in the pelvis and scapulae. The distribution is typically bilateral and symmetrical.

They are rarely seen in ribs, clavicles, spine, and skull.

Males and females are equally affected. [Read more...]

What is a Bone Island?

Also called an enostosis.

Bone island, by is a focus of mature cortical bone within the cancellous bone.

Bone island is thought by some to be a tumor-like condition and by others a hamartoma. Most likely, the lesion is congenital or developmental in origin and reflects failure of resorption during endochondral ossification.

Mostly, the bone island is asymptomatic and the lesion is usually an incidental finding.

Pelvis, femur, and other long bones are most common sites though it may be found anywhere in the skeleton. Bone islands usually are 1 mm to 2 cm in diameter. When bone islands are larger than 2 cm, they are classified as giant bone islands. [Read more...]

What is Hamartoma

A hamartoma is a benign  tumor like mass composed of of an overgrowth of mature cells and tissues normally present in the affected part, but with disorganization and often with one element predominating.

A bone island is an example of an hamartoma.

It is not a tumor in true sense and is considered a developmental error. It can occur at a number of sites in the body.

Though itself non neoplastic by definition, tissue in the hamartoma have been noticed to show neoplastic changes in some of the cases. [Read more...]

Cabozantinib Effective In Reducing Prostate Cancer Spread To Bone

Cabozanitib has demonstrated dramatic and rapid effects on prostate cancer that had spread to the bone. Tumors were reduced on bone scans, bone pain decreased after patients received cabozantinib.

This has been reported according to a study reported by University of Michigan Comprehensive Cancer Center researchers.

The study has been published in Journal of Clinical Oncology.

About two-thirds of patients treated with cabozantinib had improvements on their bone scans, with 12 percent seeing complete resolution of uptake on bone scan.

Bone is the major site where prostate tumor spreads and the tumor becomes challenging to treat when once it becomes resistant to hormone based therapies. [Read more...]

Xray of Septate Lytic Lesion of Proximal Phalanx of Little Finger

Xray of septate lytic lesion involving proximal phalanx of little finger.

Lytic Lesion of Proximal Phalanx of Little Finger

Lytic Lesion of Proximal Phalanx of Little Finger

Associated details were not found with the file. So nature of lytic lesion cannot be said.

Xray and CT of Chondrosarcoma of Cuboid

Xray and CT of chondrosarcoma of cuboid of the patient whose clinical photograph is here.

Xray first. AP and oblique views were done. Both suggest that lesion is probably coming from cuboid but a better investigation needed to confirm the origin and other details.

AP and Oblique Views of Foot Showing A Bony Lesion Probably From Cuboid

AP and Oblique Views of Foot Showing A Bony Lesion Probably From Cuboid

CT scan confirms the origin as cuboid. [Read more...]

Clinical Photograph of Tumor In Foot

Large tumorous growth in lateral aspect of foot.

A clinical photograph of foot tumor

Tumor In Foot on Lateral aspect - A Clinical Photograph


The tumor was found to bechodrosarcoma of cuboid bone of the foot.

Classification of Bone Tumours [WHO]

Cartilage Tumours

Osteochondroma

Chondroma

  • Enchondroma
  • Periosteal chondroma
  • Multiple chondromatosis

Chondroblastoma

Chondromyxoid fibroma [Read more...]

Metastatic Bone Disease

After lung and liver, bone is considered to be third m0st common organ involved by metastases. In breast cancer, the bone is second most common site for metastases.

Metastases in bone need early detection and aggressive management.

Aims of the treatment in metastatic bone disease are

  • Pain relief
  • Preservation/restoration of the function
  • Local tumor control
  • Skeletal staabilization

The metastatic spread to the bone is hematogenous and therefore affects vascularised parts especially the axial skeleton.

Presentation

The patient with bony metastases may present by any of the following

  • Pain
  • Pathological fracture
  • Hypercalcemia of malignancy
  • Neurological deficit in case of vertebral involvement

Evaluation

  • Detailed clinical history
  • High index of suspicion
  • Clinical examination
  • Radio imaging – Plain radiographs, CT, MRI as required
  • Scintigraphy
  • Bone Scan
  • Hematological investigations – Would be guided by patient profile
    • PTH level
    • Serum electrophoresis
    • Bence Jones protiens
  • Biochemical markers for malignancy
  • Chest radiographs
  • Skeletal survey
  • Biopsy
    • CT guided biopsy
    • Open biopsy
    • Aspiration

Special Investigations

Positron emission tomography is helpful in evaluating response to chemotherapy and treatment guidanc

Angiography is used in vascular or very large tumors or aneurysmal bone cysts to identify the feeder vessel or embolize it preoperatively.

Treatment

There are three approaches to metastases and role of each would depend on type of metastatic tumor, location and extent of metastases.

  • Systemic Therapy
  • Radiotherapy
  • Surgery

Systemic Therapy

  • Chemotherapy
  • Bone marrow transplant
  • Hormone therapy
  • Immunotherapy

Radiotherapy

Radiotherapy is done for suppression of tumor growth  and pain relief.

Surgery

Surgery is done either for removal of tumor or fixation of pathological fractures or to carry out amputaion in case of unsalvageable  limbs. In case of joint is destroyed by tumor or needs to be taken out, endoprosthesis or arthrodesis is considered.