Alendronate Does Not Reduce Fractures in Pediatric Osteogenesis Imperfecta

Oral bisphosphonate alendronate does noot reduce the incidence of fractures in children with osteogenesis imperfecta. This has been suggested by findings findings published November 24th online in The Journal of Clinical Endocrinology & Metabolism.

With an objective  to study the efficacy and safety of daily oral alendronate  in children with osteogenesis imperfecta, Dr Ward et al conducted a multicenter, double-blind, randomized, placebo-controlled study.

The study included 139 children between  4–19 years of age having  with type I, III, or IV osteogenesis imperfecta. [Read more...]

Zoledronic Acid Increases Survival In Addition To Prevention Of Skeletal Events In Multiple Myeloma

A study by Prof Gareth J Morgan et al reports that  first line treatment with zoledronic acid not only prevents skeletal events but also has antimyeloma effects. The study has been published in Lancet, December issue.

Zoledronic acid is a drug  that belongs to bisphosphonates group. Bisphosphonates have been used to reduce the risk of skeletal events in patients with malignant bone disease. The present study was a randomized controlled trial between zoledroninc acid and colodronic acid, another bisphosphonate.

In the study, patients of age 18 years or older with newly diagnosed multiple myeloma were enrolled from 120 centres in the UK. Computer-generated randomisation sequence was used to allocate patients equally, via an automated telephone service, to receive 4 mg zoledronic acid as an infusion every 3–4 weeks or 1600 mg oral clodronic acid daily. [Read more...]

Smoking Causes Greater Risk For Rheumatoid Arthrits

Cigarette smoking is linked to a greater risk for rheumatoid arthritis  in African Americans, according to the results of a study reported in the December issue of Arthritis & Rheumatism.

The study cohort consisted of 605 African American patients with rheumatoid arthritis and 255 healthy control participants to evaluate the associations of cigarette smoking with rheumatoid arthritis in African Americans and to examine the effect of the HLA-DRB1 shared epitope  on this association

An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells

Participants were evaluated  to determine associations of smoking with RA and additive and multiplicative shared epitope  smoking interactions. [Read more...]

Nutrient Rich Diet May Reduce Risk Of Low Trauma Fracture

A diet containing dense quantities of nutrients [High in vegetables, fruit and whole grains] may reduce the risk for low-trauma fracture, especially in older women. This has been suggested by the  results of a retrospective cohort study reported online November 10 in the American Journal of Clinical Nutrition.

The study composed of randomly selected, population-based cohort enrolled in the Canadian Multicentre Osteoporosis Study, the investigators aimed to determine the association between dietary patterns and incident fracture and to evaluate whether body mass index (BMI), BMD, or falls affected this relationship.

In second year of the study (1997-1999), they used self-administered food frequency questionnaires to evaluate dietary patterns.

The main study endpoint was low-trauma fracture occurring before the 10th annual follow-up in 2005 to 2007.

Two dietary patterns were observed

  • Nutrient dense, which emphasized intake of fruit, vegetables, and whole grains
  • Energy dense, which had higher intake of soft drinks, potato chips, French fries, meats, and desserts.

Nutrient Dense Pattern was associated with lower rate of fractures occuring as a result of low trauma. These associations were independent of BMI, BMD, falls, and demographic factors.

No associations with fracture were identified for the energy-dense pattern.

Limitations of this study acknowledged by the study authors include

  • Lack of assessment of possible intermediate factors such as weight or BMD change
  • Limited scope and specified portion size of the food frequency questionnaire
  • Underrepresentation of ethnic minorities
  • Possible residual confounding.

The Canadian Multicentre Osteoporosis Study was funded by the Canadian Institutes of Health Research, Merck-Frosst Canada Ltd, Eli Lilly Canada Inc, Novartis Pharmaceuticals Inc, The Alliance for Better Bone Health, Sanofi-Aventis, Procter & Gamble Pharmaceuticals Canada Inc, The Dairy Farmers of Canada, and The Arthritis Society.

Am J Clin Nutr. Published online November 10, 2010.

Note:

It is time to drop that cola and throw those chips. Healthy eating habits can be cutivated and go long way in protecting our body from the sickness. The new study in fact emphasizes the importance of fruits, vegetables and wholegrains.

Drugs For Rheumatoid Arthritis Less Effective In Obese Patients

A small study has suggested that obese adults with rheumatoid arthritis may be less likely than thinner people to respond to some of the newer medications for the disease.

The study included 89 patients who were put on infiximab and it was found that found obese patients improved less than leaner ones.

The study has been published in online November 8th in Arthritis & Rheumatism,

It is not clear why does this occur but  adipocytokines — inflammation-promoting proteins produced by fat tissue  are thought to play a role.

This may send an alert to the physicians that TNF blockers might be relatively less effective in obese people.

Denosumab Use Approved In Cancer Patients For Prevention Of Skeletal Complications

The US Food and Drug Administration has approved drug denosumab for use to prevention of to prevent skeletal complications in cancer patients with solid tumors and bone metastases.

The drug has already been approved and in market for postmenopausal osteoporosis.

The drug is used in different doses in in these two conditions. [Read more...]

FDA Approves Duloxetine For Chronic Musculoskeletal Pain

The United States Food and Drug Administration has approved duloxetine HCl delayed-release capsules for treatment of chronic musculoskeletal pain.

That gives many of the chronic pain patients another treatment option.

Duloxetine has been approved for both chronic low back pain and osteoarthritis. The decision was based on data from 4 double-blind, randomized clinical trials.

The recommended dose is 60 mg daily. [Read more...]

New Method Developed For MRI To Detect Early Osteoarthritis In Knee

A research conducted by New York University have developed a method to use MRI to examine sodium ions in cartilage and view the development of osteoarthritis in knee joints.

This may provide a noninvasive method to diagnose osteoarthritis in its very early stages. It would also help to calculate measures of cartilage assessments.

The measurement reveal the location of glycosaminoglycans  in cartilage tissues. Glycosaminoglycans serve as the building blocks of cartilage  apart from other functions in the human body. [Read more...]

Study Indicates That Early Reconstruction of Anterior Cruciate Ligament Tear In Children Shows Better Results

A new srudy has indicated that in athletes 14 years of age and younger with anterior cruciate ligament (ACL) tears, early reconstruction results in significantly improved outcomes without growth disturbance. A reconstruction done within 12 weeks of injury is defined as early reconstruction. In addition to better function the early intervention also saves money. [Read more...]

Anyplex MDR-TB Test – New Test For Detection Of Multidrug Resistance Tuberculosis Developed

Tuberculosis is a chronic infection that has made a worldwide resurgence due to advent of HIV and AIDS. In addition to this there is rise of drug-resistant mycobacterium tuberculosis which further threatens the global TB control efforts. Therefore it is very necessary to have diagnostic measures that detect resistance of the drugs to a particular strain fast. Conventional methods take months to detect the resistance and the search is on for new ways to detect the resistance or multi drug resistance in patients of tuberculosis. [Read more...]