Dose of Vitamin D May Be Important In Fracture Prevention

In a recently published paper in march issue Archives of Internal Medicine, prevention of nonvertebral fractures with vitamin D is dose-dependent for individuals aged 65 years or older. The paper is based on meta-analysis of of randomized controlled trials.

Researchers found a significant positive trend between serum 25-hydroxyvitamin D concentrations and hip bone density and lower extremity strength. The reviewers identified 12 double-blind RCTs for nonvertebral fractures, enrolling a total of 42,279 subjects, and 8 RCTs for hip fractures, enrolling a total of 40,886 subjects, which compared the effects of oral vitamin D, with or without calcium, with those of calcium alone or of placebo. [Read more...]

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Removable Splints Are As Good As Casts For Minor Wrist Fractures In Children

A latest review by at Cochraine Library, an international nonprofit, independent organization that produces and disseminates systematic reviews of health care interventions, has concluded that removable splints and plaster casts appears to be equally safe and effective for treating minor “buckle” wrist fractures in children.

Buckle fracture or Torus fractures, are extremely common injuries seen in children. Because children have softer bones, one side of the bone may buckle upon itself without disrupting the other side; this is also known as an incomplete fracture.

The word torus is derived from the Latin word ‘Tori’ meaning swelling or protuberance. Children commonly sustain this injury by falling on an outstretched hand. [Read more...]

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Oral Bisphosphonates May Cause Esophageal Cancer

N Engl J Med. 2009;1360:89-90

There have been reports of esophageal cancer in patients who had been taking oral bisphosphonate drugs for osteoporosis. This has been reported by an official from the Food and Drug Administration (FDA) in the January 1 issue of the New England Journal of Medicine.

Twenty-three cases including 8 fatal reported in the United States, between October 1995 May 2008, all of them in association with alendronate. Fosamax, a popular band from Merck contains alendronate. [Read more...]

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Height Gene Linked To Osteoarthritis Too

Common genetic variants associated with osteoarthritis may also play a role in determining a person’s height, according to a U.S.-European study which included an analysis of the genomes of more than 35,000 people.

Many genes control height, but only a few are associated with osteoarthritis.

The findings also add to overall understanding of height. [Read more...]

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Seat Belt Use by Pregnant Women Could Save 200 Fetuses a Year

Pregnant women should wear seat belts, not only to save themselves in the event of a car accident but also to save their fetus.

According to a new study published in the April issue of the American Journal of Obstetrics & Gynecology, almost 200 fetuses each year or half of all fetal losses in motor-vehicle crashes could be saved if pregnant women buckled up properly.

Dr. Richard Jones, assistant professor of obstetrics/gynecology at Texas A&M Health Science Center College of Medicine, said, “Pregnant women need to be properly wearing seat belts,” with the best type of seat belt the three-point restraint. [Read more...]

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Vertebroplasty Provides Significant Pain Relief In Osteoporotic Fractures

In osteoporosis patients with spinal fractures, vertebroplasty provides significant pain relief and helps decrease disability, according to a new study.

Vertebroplasty is a procedure that involves injection of medical-grade bone cement into a fractured vertebra to shore up the fracture and provide pain relief. It’s used to treat painful vertebral compression fractures that don’t respond to conventional medical therapy with analgesics or narcotics. [Read more...]

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Study Indicates Teriparatide As Useful Drug In Osteoporosis Treatment

Teriparatide, a drug that contains a synthetic form of a natural human hormone call parathyroid hormone, is a useful treatment for the bone-thinning disease osteoporosis even in patients who have already been treated with “bisphosphonate” drugs, such as Allendronate or zoledronate, new research shows.

Bisphosphonate drugs strengthen bones by blocking the body’s cells that break down bone. Teriparatide, works by enhancing the activity of cells that build bone.

Teriparatide may be prescribed as a second-line treatment for severe osteoporosis, but the effect of prior bisphosphonate therapy on the response to the drug is unclear, according to the report in the Journal of Clinical Endocrinology and Metabolism. [Read more...]

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Variants In LRP5 Gene Affect Bone Density-Linked With Osteoporosis

Common variants in a gene called LRP5 affect bone density and the risk of developing osteoporosis, according to a new study.

However, the impact of these variants on risk is modest. [Read more...]

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Glucosamine No Good For Hip Arthritis-Study

Glucosamine sulfate, a popular dietary supplement purported to ease the pain and inflammation of arthritis, does not seem to help people with arthritis in their hips.

That’s the conclusion of a study that compared the use of glucosamine to a placebo for the treatment of mild to moderate hip arthritis. [Read more...]

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Strontium Ranelate May Reduce Backpain In Osteoarthritis of spine

A compound called strontium ranelate may reduce back pain in women with osteoporosis and osteoarthritis of the spine, according to new study. The compound may also delay progression of spinal osteoarthritis. [Read more...]

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