Osteoporosis – Denosumab+Teriparatide Superior To Single Drug Treatment

Two osteoporosis drugs denosumab and teriparatide, when combined together in therapy, produce  increase bone density better than treatment with either drug alone. This has been reported by a study, a small clinical trial to be published in journal Lancet.

The study by Joy N Tsai et al has been conducted in Massachusetts General Hospital conducted a 12-month trial in women with postmenopausal osteoporosis.

From September, 2009, to January, 2011, 100 women of age equal to or greater than 45 years were subjected to  this randomized, controlled trial. [Read more...]

DJ1 Protein – The New Protein To Promote Formation of New Bone In Osteoporosis

Researchers from Korea have reported a new potein ‘DJ-1 protein’  which can be used to promote the formation of new bone tissue in patients suffering from osteoporosis by improving communication between bone making cells (osteoblasts) and blood vessel (endothelial) cells.

The research has been published in Nature Communications.

The study by Kim and colleagues reveal DJ-1 as a novel mediator of the cross-talk between osteoblasts and endothelial cells by screening molecules secreted from as yet undifferentiated human skeletal cells.

The researchers showed that DJ-1 stimulates the differentiation of the yet undifferentiated skeletal cells into bone cells by activating fibroblasts, cells which in turn ensure connective tissue growth. [Read more...]

Obese Children Have Low Quality Bones

A recent study published in Clinical Endocrinology has reported that obese children have small and poor quality metacarpal bones.

The study by Longhi and colleagues, published in January 2013 issue of the journal is a cross sectional observational study that included 123 children between 8-14 years.

The study used digital xrays to evaluated  2nd metacarpal bone for the determination of the outer  and inner diameter, cortical area, medullary endocortical area, metacarpal index and bone strength.

Phalangeal ultrasonography was done in  98 subjects. [Read more...]

What is Digital Xray Radiogrammetry?

Osteoporosis is defined as a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fractures.

Measurement of bone mineral density forms the basis for the working definition of osteoporosis.

Fractures are the hallmark of osteoporosis. The risk of fracture in osteoporosis is determined by the risk of fall, the force of impact and the strength of bone. Reduced bone mineral density being an important component of fracture risk in osteoporosis.

[Read more...]

Digital X-ray Radiogrammetry Is Effective To Assess Risk of Hip Fractures

Digital X-ray radiogrammetry or DXR is a method used to assess bone mineral density from the xrays.

A new study from Karolinska Institute in Sweden shows that digital xray radiogrammetry used on standard hand radiographs can help to identify patients with a higher risk of hip fracture.

DXR, according to researchers  is fully comparable with other, more costly methods.

The study by  M. L. Wilczek, J. Kälvesten, J. Algulin, O. Beiki  and TB Brismar has been published in November issue of European Radiology.

Osteoporosis disease is estimated to effect some 200 million women worldwide and every year  approximately 1.7 million hip fractures occur worldwide  mainly in elderly people and women with osteoporosis. [Read more...]

Sedentary Behavior In Teenage Children Leads To Bone Loss

Should Exercise To Ward off Bone Loss

A new research published in BMC Public Health, online on 13 November 2012 has reported that children who spend a lot of time sitting ave lower bone mass and urge the teenagers to play more to fight the bone loss.

The study further says that playing football or running for at least three hours a week could help teenagers counteract the potential damage to their bone health caused by prolonged spells of sitting

The study has been authored by Marco and colleagues. [Read more...]

Bariatric Surgery May Cause Bone Loss

Also known as weight loss surgery, bariatric surgery consists of procedures which limit the amount of intake and thus affect weight loss. it is an effective method to treat obesity and is being performed on increasing numbers of people worldwide, including teenagers.

But some of the bariatric surgeries may also cause bone loss, particularly when carried out on young people who have not yet reached their peak bone mass.

This has been reported by a recent review of current literature in the journal Obesity Reviews, published online on 25th Oct.

The study has been authored by Brzozowska and colleagues from Sydney’s Garvan Institute of Medical Research. [Read more...]

Epidural Steroid Injections For Backpain May Increase Vertebral Fractures

A new study funded by Henry Ford Hospital has reported that  risk of vertebral fractures increases  in patients who receive epidural injections for back pain.

It is a retrospective study that involved 6,000 patients[3840 -women, 2160-men] treated for back pain between 2007 and 2010. The study’s lead author is Shlomo Mandel who is also a physician in Henry Ford hospital.

About  3,000 patients received at least one steroid injection and 3,000 patients did not receive steroid injection.

The mean age of patients was 66 years.

Incidence of bone fractures in each group was analyzed. [Read more...]

Novel Exercise Program for Preventing Falls In Older People

Balancing and strengthening of the everyday activities my help older people prevent falls and improve overall strength and balance. This has been suggested by a study published in the British Medical Journal online on August 7.

Lindy Clemson and colleagues conducted a 3-group randomized trial in which residents of Sydney older than 70 years who had 2 or more falls or 1 injurious fall within the previous year. The residents were recruited and randomly assigned to one of the following interventions

  • Novel activity-integrated exercise program called Lifestyle integrated Functional Exercise (LiFE)
  • A structured exercise program
  • A gentle exercise control program.

Following patients were excluded from study [Read more...]

Early Menopause Is A Predictor Of Higher Risk Of Osteoprosis and Fractures

A new Swedish study has reported that women who experienced menopause before age 47 years were almost twice as likely to develop osteoporosis in later life. Not only this, it also leads to increased risk for fragility fractures and death.

The study conducted by Ola Svejme and colleagues has been published by BJOG: An International Journal of Obstetrics and Gynaecology online on 25 April.

A population-based cohort study, the present study included 390 white north European women were followed for 34 years beginning at 48 years of age. They were divided into 2 groups at baseline according to age at menopause occurrence (<47 years and >47 years).

Bone mineral density was measured and recorded at the beginning and again at 77 years.

The mortality rate and fracture incidence were identified from hospital records and national population registers and were recorded through age 82 years.

The results showed that 56% women with early menopause and 30% women with late menopause had developed osteoporosis.

Women with early menopause were also significantly more likely to have sustained at least 1 fragility fracture. The mortality rate in the early menopause group was 52.4%, compared with 35.2% in the late menopause group. [Read more...]