Causes of Pathological Fractures In Children

A pathological fracture is defined as a fracture that occurs through abnormal bone, a  bone that lacks normal biomechanical and viscoelastic properties.

Pathological fractures may result from generalized bone weakness caused by an external process like radiation. Another example of external cause is hole caused by a procedure like fixation or biopsy.

Most of the fractures, however, have internal causes which could be localized or generalized.

Generalized bone Diseases Causing Pathological Fractures In Children

  • Rickets
  • Osteogenesis imperfecta
  • Osteopetrosis
  • Antley-Bixler syndrome
  • Cytochrome P450 oxidoreductase deficiency
  • Jaffe-Campanacci syndrome
  • Bruck syndrome
  • Malabsorption syndrome
  • Cushing’s syndrome
  • Scurvy
  • Carbonic anhydrase type 2 deficiency
  • Metastases
  • Hypophosphatasia
  • Polyostotic osteolytic expansile dysplasia
  • Copper deficiency
  • Osteoporosis-pseudoglioma syndrome
  • Pyknodysostosis
  • Hyperparathyroidism
  • Osteoporosis
  • Anorexia nervosa
  • Gorham’s vanishing bone disease

Localized Conditions Causing Pathological Fractures In Children

  • Enchondroma
  • Infection-Osteomyelitis
  • Bone Tumors – Benign and malignant
  • Tumor like lesions of bone
  • Bone Cyst
  • Retrauma in recently united bone

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