Hyaluronan (hyaluronic acid or hyaluronate or HA) is an anionic, nonsulfated glycosaminoglycan distributed widely throughout body and has highest concentrations in fluids in the eyes and joints.
In body, hyaluronic acid is involved in the wound repair process, inflammation, reepithelization of normal epidermis, cancer metastases.
Hyaluronan is used in eye surgery, osteoarthritis of knee, atopic dermatitis, tumor marker for prostate and breast cancer, to prevent postoperative adhesions in pelvic surgery.
Hyaluronan is a common ingredient in skin-care products.
Commercially produced hyaluronic acid is extracted from sources like animal synovial fluid, umbilical cord, skin, and rooster comb, or made by bacteria in the laboratory.
It is also used as a lip filler in plastic surgery.
Recent research is aiming at development of antiaging products.