Common genetic variants associated with osteoarthritis may also play a role in determining a person’s height, according to a U.S.-European study which included an analysis of the genomes of more than 35,000 people.
Many genes control height, but only a few are associated with osteoarthritis.
The findings also add to overall understanding of height.
“It is useful to know all genes responsible for height variation, so we are reassured if our baby is shorter than others because he has a collection of “short” alleles on his DNA, and not because he has something wrong, like a metabolism disorder,” study co-author Serena Sanna said in a prepared statement.
The study was published online Jan. 13 in Nature Genetics.
It’s believed that both short and tall extremes of height may be associated with osteoarthritis, but for different reasons. Longer bones may place greater levels of stress on the joints, while shorter bones and/or less cartilage may make joints more susceptible to damage.
Source:Medline Plus
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