Osteoid osteoma is a benign [non-cancerous] tumor that consists of osteblastic [growing cells] mass called a nidus. Nidus is very rich in blood supply. Nidus is surrounded by a zone of sclerotic but otherwise normal bone. The zone of sclerosis represents a secondary reversible change that gradually disappears after the removal of the nidus.This sclerosis is kind of reaction to the tumor because it reverses on removal of nidus. The nidus tissue has a limited local growth potential and usually is less than 2 cm in diameter.
Osteoid osteoma accounting for 5% of all primary bone tumors.
Osteoid osteoma is mostly seen 10-30 years of age and about 90% of cases occur in patients younger than 25 years. It has a been reported between aged 8 months to 70 years though.
Men are affected more frequently than women and there is no racial predilection.
Distribution of Osteoid Osteoma in Body
Osteoid osteoma can occur anywhere in the body. It can involve a single bone or several bones.
Cortex of the shafts of long bones is affected in 80-90% of cases. It is also reported in the epiphyseal and metaphyseal regions of both small and large bones of the axial and appendicular skeletons, especially the femur, tibia, and humerus.
The lower extremities are the most common sites of osteoid osteomas with femur being involved in almost 60% of the cases, followed by tibia.
The femoral neck is the single most frequent anatomic site.The tibia is the second most frequently involved long tubular bone.
Fibular lesions are very rare.
In the upper limbs, the humerus is the most frequently involved bone, and a majority of cases occur around the elbow joint. Involvement of the distal ulna and radius is very rare.
10 percent to 15 percent of Osteoid osteomas occur in the vertebral column. Most frequently, they are located in the lumbar and lower thoracic portions of the spine.
Spinal lesions are difficult to detect on plain radiographs and are known to be responsible for unexplained backache and painful scoliosis.
In vertebrae the nidus is most frequently located in the posterior arch.
Magnetic resonance imaging also may facilitate the identification of an inconspicuous nidus.
Other frequent locations include articular facets and pedicles, the transverse and spinous processes.
A primary tumor in the vertebral body is extremely rare.
10 percent of osteoid osteomas occur in the small bones of the hands and feet. The tumour occurs twice more commonly in hands than feet.
In the hands, the phalanges are the most frequently involved sites.
Osteoid osteomas located within the articular capsule are rare . Elbow, hip, and ankle joints are most commonly involved.
Juxtaarticular Osteoid Osteomas are typically associated with nonspecific symptoms similar to other common joint disorders.
Pain is usually less intense when compard to osteoid osteomas of other region, and so is its reponse to its response to nonsteroidal anti-inflammatory drugs is also milder.
The intraarticular nidus is difficult to identify, and there is no periosteal reaction.
The diagnosis be delayed in such cases.
Subperiosteal osteoid osteoma is a relatively rare lesion. Conventional radiographs demonstrate a lucent lesion on the surface of bone with adjacent periosteal reaction.
The nidus is typically radiolucent with no evidence of central opacity.
This osteoid oseoma is larger in size because the restricting compressive force on side of periosteum is absent. The subperiosteal lesions are on average less sclerotic and have thinner trabeculae and a greater proportion of stromal tissue compared with intracortical lesions.
Dull aching pain at the site of the lesion is the main presenting symptom of the presentation of the osteoid osteoma. Pain is usually worse at night and diminishes by morning in majority of patients. About 30% people report awakening in the night due to pain.
The symptoms disappear dramatically after taking non-steroidal anti-inflammatory medication.
In juxtaarticular lesion joint pain and swelling of the joint may occur. Lesion of the spine may produce painful scoliosis, or radicular pain or referred-type pain into the lower limb or upper limb.
Limp may occur in some patient.
Ome patients may present with swelling without pain. It usually occur in diaphyseal regions of bone.
Lesions of the small bones may lead to expansion of the bone and may present protuberance or swelling of the region, macrodactyly [enlarged digit]
Tenderness is present in more than 50% of patients and usually occurs with subperiosteal lesions and is relatively uncommon with medullary lesions.
Local warmth and redness is also a less common finding. Joint swelling and synovitis may be found in intracapsular lesions. Soft-tissue swelling, contractures, and a soft-tissue mass can be an associated finding .
In cases of intracapsular lesions, synovium is generally edematous and thickened. Synovial changes spontaneously subside after removal of the nidus.
Usually have normal blood and chemistry findings.
The radiographic features of osteoid osteoma are characteristic but it could be along before the changes are noticeable in x-rays.
Radiographs reveal a well-demarcated lytic lesion (nidus) surrounded by a distinct zone of sclerosis. A zone of central opacity that represents a more sclerosis.
A zone of central opacity that represents a more slecrotic portion of the nidus and is surrounded by a lucent halo may be present within the nidus.
The intracortical lesions of long bones may produce sclerotic thickening of the cortex with sometimes obscure the nidus.
In many cases, nidus may not be visible, so additional imaging techniques, such as computed tomography, radioisotope scanning, and magnetic resonance imaging, may be necessary.
In vertebral locations, radiographs may show increased density of the pedicle, loss of a distinct contour, or both. The nidus is often not seen.Exact anatomic localization of the nidus which usually is present in the area of the posterior arch or at the base of a pedicle may require computed tomography.
– Associated findings
- In small bones, the nidus is usually not surrounded by a distinct zone of sclerosis. The bone contour can be expanded, and the entire bone can be markedly enlarged.
- Intraarticular osteoid osteoma can provoke periarticular osteoporosis and induce development of secondary osteoarthritis with osteophyte formation and joint destruction.
- Osteoid osteoma may induce premature fusion of the epiphysis in rare cases.
Underlying Osteoid osteoma be ruled out in virtually all cases of unexplained back pain and painful scoliosis that occur in children and young adults.
In some patients, clinical symptoms may suggest a neurologic disorder, lumbar disc disease, or both conditions.
In small bones of hand and foot, osteoid osteoma can mimic an inflammatory process. It is not unusual for a patient with osteoid osteoma of the hands and feet to be treated initially for chronic osteomyelitis or other inflammatory conditions.
Other conditions which might appear similar in symptoms and signs
- Chronic and acute osteomyelits
- Bone abscess
- Intracortical hemangioma
- Bone island
- Stress fracture
- Ewing’s sarcoma
- Intracortical osteosarcoma.
Initial treatment of osteoid osteoma remains nonoperative, with medications. Some of these patients can be managed with prolonged treatment with nonsteroidal anti-inflammatory durgs. Salicylates and naproxen are most used non steroidal antiinflammatory drugs drugs . Because of these drugs work by inhibition of prostaglandin, prostaglandin role has been postulated in cases of osteoid osteoma.
Some patients have good pain relief and are continued with this. However, the effect may diminish in others and surgery may be chosen.
Osteoid osteomas are known to regress with time in some cases.
In patients whose pain does not respond to drug treatment or there is a problem with non steroidal anti-inflammatory drugs, surgery should be considered. Patients who find difficult to restrict activity are also candidates for surgery.
Surgery, whether conventional or minimally invasive, seeks complete excision of the nidus.
En bloc resection
En bloc resection is the resection of the lesion in toto to ensure complete removal of the nidus.
Disadvantages of this procedure include excessive resection of normal bone in the effort to completely excise the lesion.
The procedure is contraindicated in patients with lesions in areas difficult to access, such as the acetabulum or femoral head and neck.
En bloc surgical resection of the tumor is associated with longer healing times, prolonged hospital stay, fractures in perioperative period, need for bone grafting and internal fixation, joint stiffness etc.
Unroofing and curettage
In this procedure, overlying bone is removed and the tumor is excised excision with curettes and burrs. It can achieve cure rate of 75-100%.
Unroofing and curettage is especially helpful in treating lesions in a structurally vital location, such as the femoral neck where much bone loss cannot be afforded other wise structural support for the area is disturbed.
Prophylactic internal fixation where needed may be done if the treatment weakens the remaining bone.
Similarly, spinal fusion is recommended if instability results from the treatment.
Recurrence after Open Surgery
Reported recurrence rate after open surgery is 9-28%.
Recurrence is typically observed within 1 year after excision; hence, the patient should be monitored for a minimum of 1 year.
Failure to relieve pain indicates incomplete removal of the tumor and bad prognosis
Minimally Invasive Surgery
Three hours before surgery, the radionuclide [technetium-99m-labeled hydroxymethylene diphosphonate (HMDP) and dichloromethylene diphosphonate (DMDP)] is given to the patient. Scanning after one hour localizes the hot spot.
A detector probe is then used to locate the hot spot during surgery. The method is reported to localize the nidus with precision of 2 mm enabling the excision of lesions with minimal damage to normal bone. Same probe can also determine completeness of removal.
False positive results during surgery or for completion assessment are a problem.
CT Guided Percutaneous Excision
In this method, under CT guidance, a needle is inserted in the nidus . This reduces the amount of bone removed during surgery. Postoperative CT scan and pathologic examination is done for the confirmation. Reported success rate is 83-100%.
Percutaneous Laser Photocoagulation
An optical fiber or fibers are inserted directly into the target tissue, followed by treatment with laser energy for several minutes. Cure rate of 93% and a 96% are reported after the second ablation.
Percutaneous Radiofrequency Ablation
An electrode is placed in the lesion which is coupled to a radiofrequency generator. This would lead to that produces local tissue destruction by converting radiofrequency into heat. This method can treat smaller lesion in single application. Larger lesions may require a second application.
The patients can be sent home same day and is method of choice in suitable patients. The procedure is most suited for treatment if the location of the osteoid osteoma should permit a safe access and a safe heating procedure without risking to damage nerves, major blood vessels and the skin.
[ If the tumor nidus is more than 1 cm away from these structures the procedure can usually be safely performed.]
Complete or nearly complete relief of pain often occurs within 3 days. Younger patients and lesion of 10 mm are associated with increased risk of treatment failure.
Primary cure rates are 83-94%. Cure with a second ablation procedure is approximately 100.
Patients may return to work, school and other normal activities usually within the first week after the procedure. Athletic activities are prohibited for 3 months.
It should be considered that recurrence rates of 10-20% have been described and a second procedure may sometimes be required especially in large lesions.
Percutaneous radiofrequency coagulation is currently the preferred treatment for osteoid osteoma because it does not require hospitalization, is not associated with complications, and is associated with rapid convalescence.
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