Anakinra Is Found To Be Effective In Muckle Wells Syndrome

Anakinra is  recombinant interleukin (IL)-1 receptor antagonist.  A new study published in  Arthritis & Rheumatism online has found that anakinra is safe and effective for severe Muckle-Wells syndrome.

The researchers investigated the efficacy of anakinra in 12 patients with severe Muckle Wells syndrome. Seven patients were adults and five were children.

All constitutional symptoms resolved by 2 weeks, and there was near complete resolution of musculoskeletal manifestations and significant improvement in ocular symptoms and skin manifestations. [Read more...]

What Is Muckle Wells Syndrome?

Muckle-Wells syndrome [Also known by the names of  UDA (Urticaria Deafness Amyloidosis) syndrome   is a rare autosomal dominant disease which results in

  • Sensorineural deafness
  • Recurrent hives
  • Amyloidosis - A disease where abnormal deposition of amyloid occurs in various organs.
  • Fevers
  • Painful joints (arthritis)

MWS was first described in 1962 by Thomas James Muckle and Michael Vernon Wells. It is rare disorder and exact incidence is not known. [Read more...]