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Osteoporosis – Denosumab+Teriparatide Superior To Single Drug Treatment

May 16, 2013 by Leave a Comment

Two osteoporosis drugs denosumab and teriparatide, when combined together in therapy, produce  increase bone density better than treatment with either drug alone. This has been reported by a study, a small clinical trial to be published in journal Lancet.

The study by Joy N Tsai et al has been conducted in Massachusetts General Hospital conducted a 12-month trial in women with postmenopausal osteoporosis.

From September, 2009, to January, 2011, 100 women of age equal to or greater than 45 years were subjected to  this randomized, controlled trial. [Read more...]

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What is Digital Xray Radiogrammetry?

December 18, 2012 by Leave a Comment

Osteoporosis is defined as a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fractures.

Measurement of bone mineral density forms the basis for the working definition of osteoporosis.

Fractures are the hallmark of osteoporosis. The risk of fracture in osteoporosis is determined by the risk of fall, the force of impact and the strength of bone. Reduced bone mineral density being an important component of fracture risk in osteoporosis.

[Read more...]

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Early Menopause Is A Predictor Of Higher Risk Of Osteoprosis and Fractures

May 3, 2012 by Leave a Comment

A new Swedish study has reported that women who experienced menopause before age 47 years were almost twice as likely to develop osteoporosis in later life. Not only this, it also leads to increased risk for fragility fractures and death.

The study conducted by Ola Svejme and colleagues has been published by BJOG: An International Journal of Obstetrics and Gynaecology online on 25 April.

A population-based cohort study, the present study included 390 white north European women were followed for 34 years beginning at 48 years of age. They were divided into 2 groups at baseline according to age at menopause occurrence (<47 years and >47 years).

Bone mineral density was measured and recorded at the beginning and again at 77 years.

The mortality rate and fracture incidence were identified from hospital records and national population registers and were recorded through age 82 years.

The results showed that 56% women with early menopause and 30% women with late menopause had developed osteoporosis.

Women with early menopause were also significantly more likely to have sustained at least 1 fragility fracture. The mortality rate in the early menopause group was 52.4%, compared with 35.2% in the late menopause group. [Read more...]

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What Is Osteoporosis?

October 1, 2011 by Leave a Comment

Osteoporosis is a pathological condition that affects whole of skeleton and is characterized by a low bone mass in combination with microarchitectural changes particularly in cancellous bone.

Both the factors make the bones fragile.

In a normal skeleton, bone remodeling is a quite a regulated procedure where bone resorption is coupled with bone formation.

Osteoporosis can be viewed as an imbalance of remodeling where bone loss is higher as compared to bone formation.

Two factors determine the bone mass [Bone mineral density] in later life are [Read more...]

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Use of Bisphosphonates In Osteoporosis Associated With Higher Risk Of Subtrochanteric or Femoral Shaft Fractures

February 23, 2011 by Leave a Comment

Osteoporosis as a disease is associated with significant morbidity and mortality. The studies done in the past have suggested that bisphosphonate use is associated with reduction of hip and other fractures that occur as a result of osteoprosis.

But a new study has found that women who take bisphosphonates for  five or more years have a high risk of getting a fracture in subtrochanteric or shaft of femur.

The study has been done by Laura Y. Park-Wyllie and colleagues and has been published in JAMA [Journal of American Medical Association] [Read more...]

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Nutrient Rich Diet May Reduce Risk Of Low Trauma Fracture

November 25, 2010 by Leave a Comment

A diet containing dense quantities of nutrients [High in vegetables, fruit and whole grains] may reduce the risk for low-trauma fracture, especially in older women. This has been suggested by the  results of a retrospective cohort study reported online November 10 in the American Journal of Clinical Nutrition.

The study composed of randomly selected, population-based cohort enrolled in the Canadian Multicentre Osteoporosis Study, the investigators aimed to determine the association between dietary patterns and incident fracture and to evaluate whether body mass index (BMI), BMD, or falls affected this relationship.

In second year of the study (1997-1999), they used self-administered food frequency questionnaires to evaluate dietary patterns.

The main study endpoint was low-trauma fracture occurring before the 10th annual follow-up in 2005 to 2007.

Two dietary patterns were observed

  • Nutrient dense, which emphasized intake of fruit, vegetables, and whole grains
  • Energy dense, which had higher intake of soft drinks, potato chips, French fries, meats, and desserts.

Nutrient Dense Pattern was associated with lower rate of fractures occuring as a result of low trauma. These associations were independent of BMI, BMD, falls, and demographic factors.

No associations with fracture were identified for the energy-dense pattern.

Limitations of this study acknowledged by the study authors include

  • Lack of assessment of possible intermediate factors such as weight or BMD change
  • Limited scope and specified portion size of the food frequency questionnaire
  • Underrepresentation of ethnic minorities
  • Possible residual confounding.

The Canadian Multicentre Osteoporosis Study was funded by the Canadian Institutes of Health Research, Merck-Frosst Canada Ltd, Eli Lilly Canada Inc, Novartis Pharmaceuticals Inc, The Alliance for Better Bone Health, Sanofi-Aventis, Procter & Gamble Pharmaceuticals Canada Inc, The Dairy Farmers of Canada, and The Arthritis Society.

Am J Clin Nutr. Published online November 10, 2010.

Note:

It is time to drop that cola and throw those chips. Healthy eating habits can be cutivated and go long way in protecting our body from the sickness. The new study in fact emphasizes the importance of fruits, vegetables and wholegrains.

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Oral Bisphosphonates May Cause Esophageal Cancer

January 3, 2009 by Leave a Comment

N Engl J Med. 2009;1360:89-90

There have been reports of esophageal cancer in patients who had been taking oral bisphosphonate drugs for osteoporosis. This has been reported by an official from the Food and Drug Administration (FDA) in the January 1 issue of the New England Journal of Medicine.

Twenty-three cases including 8 fatal reported in the United States, between October 1995 May 2008, all of them in association with alendronate. Fosamax, a popular band from Merck contains alendronate. [Read more...]

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Pelvic Fractures In Elderly Persons

May 6, 2008 by

Increasing number of aged people is having a profound impact on pelvic fracture management. As the number of elderly people increases, so would be old patients with increasing number of injuries.

Pelvic trauma in young individuals occur due to severe trauma in young individuals. However, the elderly people can get fractures with minor trauma due to weakened skeletal framework as a result of osteoporosis.The elderly experience higher mortality and late morbidity than younger patients with comparable injuries. [Read more...]

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Vertebroplasty Provides Significant Pain Relief In Osteoporotic Fractures

April 3, 2008 by Leave a Comment

In osteoporosis patients with spinal fractures, vertebroplasty provides significant pain relief and helps decrease disability, according to a new study.

Vertebroplasty is a procedure that involves injection of medical-grade bone cement into a fractured vertebra to shore up the fracture and provide pain relief. It’s used to treat painful vertebral compression fractures that don’t respond to conventional medical therapy with analgesics or narcotics. [Read more...]

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Study Indicates Teriparatide As Useful Drug In Osteoporosis Treatment

April 3, 2008 by Leave a Comment

Teriparatide, a drug that contains a synthetic form of a natural human hormone call parathyroid hormone, is a useful treatment for the bone-thinning disease osteoporosis even in patients who have already been treated with “bisphosphonate” drugs, such as Allendronate or zoledronate, new research shows.

Bisphosphonate drugs strengthen bones by blocking the body’s cells that break down bone. Teriparatide, works by enhancing the activity of cells that build bone.

Teriparatide may be prescribed as a second-line treatment for severe osteoporosis, but the effect of prior bisphosphonate therapy on the response to the drug is unclear, according to the report in the Journal of Clinical Endocrinology and Metabolism. [Read more...]

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