Granulation tissue is collagen-rich tissue formed during proliferative phase of wound healing.
When initially formed, the granulation tissue is light red or dark pink in color and rich in capillary blood vessels. It is soft, moist and granular in appearance.
It is a natural stage in wound healing. But sometimes there is an overproduction and granulation tissue found in abnormal quantity, a condition known as proud flesh.
Granulation tissue is composed of tissue matrix supporting a variety of cell type which function to form extracellular matrix, enagage in loacl immunity of the tissue and formation of blood vessels [angiogenesis]
A granulation tissue on external surface would leave a scar, the size of which depend on the extent of injury and thus granulation tissue and the amount of granulation tissue produced.
Inside the body, especially in tubular structures like trachea or urethra, the garnualtion tissue may result in narrowing of the lumen of the structure. If formed in cavities, it may result in adhesions.« Back to Glossary Index