Kyphotic Deformity of Spine in Tuberculosis

Neurological complications (paraplegia or quadriplegia) and spinal deformity are the most dreaded complications of tuberculosis of spine.

The sequelae of these two complications affect the quality and span of life. Almost all tuberculosis of spine, even if they are treated well, leave behind some amount of kyphosis in different segments of spine. Persistent spinal deformity affects the biomechanics of all segments of the spine.

The advent of effective antituberculous chemotherapy has made uncomplicated spinal tuberculosis largely a medical dis­ease. Attention has now turned to the prob­lem of progressive deformity. In endemic regions,  about 80% of patients with spinal involvement have some sort of detectable kyphosis at the time of presentation.

Patients treated conserva­tively have an average have of 15 de­grees deformity and 3-5% develop deformity greater than 60 degree.

Severe kyphosis is cosmetically and functionally disabling and can lead to late-onset paraple­gia. Prevention of deformity should be an essential aspect of any treatment schedule in spinal tuberculosis as Correction of established deformity is difficult and hazardous, with a high compli­cation rate.

Pathology of Kyphotic Deformity In Spinal Tuberculosis

In most of the cases, the tuberculous lesion starts as a paradiscal inflammation. Gradually, as disease progresses the vertebral end plates become structurally weak and intervertebral disc starts ballooning/herniating into the diseased vertebral body, visualized on x-ray as reduced disc space.

The vertebral body loses more anterior height than posterior as the line of weight transmission is anterior. The severity of kyphosis depends on the number of vertebral bodies affected, severity of loss of anterior vertebral body height and segment of the spine affected.

A case of dorsal spine or dorsolumbar spinal tuberculosis with three or more vertebral body affection is more likely to develop moderate to severe kyphotic deformity.

In cervical and lumbar spine, the line of weight transmission is in posterior half of vertebral bodies. Therefore, there is first obliteration of natural cervical and/or lumbar lordosis and later on kyphosis starts appearing.

In a usual scenario, in developing nations, about 95% patients show a clinically detectable kyphosis or reversal of normal lordosis, by the time patient seeks consultation of specialist.

Natural History of Kyphotic Deformity

Tuberculosis preferentially affects the anterior structures of the vertebral column in over 90% cases. Although chemotherapy may inactivate the disease, vertebral col­lapse will continue until the healthy verte­bral bodies in the region of the kyphosis meet anteriorly and consolidate.

In paradiscal le­sions, the intervening discs are destroyed early, allowing the cancellous bone on ei­ther side to come into contact and achieve bony fusion, which is the hallmark of heal­ing of spinal tuberculosis. When the disease is severe with complete destruction of en­tire vertebral segments, the defect in the anterior column is too extensive for such a healing process to occur.

The severity of deformity depends on the extent of de­struction, the age of the patient, and the level of lesion.

The deformity progresses in two distinct phases

Phase I

The changes in the first 18 months during the period of activity of the disease.

Phase II

Changes that occurred after the disease was cured were termed Phase II or healed phase changes.

Adults had a lesser deformity at presen­tation, and lesser increase during Phase I, and virtually no change once disease cure^,

Children had a higher deformity at presentation, a greater tendency for col­lapse during the active phase of the disease, and continued and variable progression even after the disease was cured and growth was completed

This could be due to

• Increased severity of destruction at presentation
• In­creased flexibility of the spine in children
• Variable destruction of the growth plates in­terfering with future growth
• The suppressive effect of the mechanical forces of kyphosis

Types of Progression of Kyphosis

• Type 1
  • Progression shows contin­ued progress through the entire period of growth.
  • Continu­ously after Phase I (Type 1 A)
  •  3 to 6 years after the disease was cured (Type 1B).
• Type II
  • Progression shows beneficial effects during growth with a decrease in deformity after healing of the dis­ease.
  • IIA – This can occur immediately after Phase 1
  • IIB – after 3 to 6 years.

The Influence of the Level of Lesion

Patients with dorsal lesions have the greatest deformity at the time of presentation

Patients with dorsolumbar lesions have the worst prog­nosis because of a greater collapse during the active phase and a greater deterioration in children during the growth period. Patients with lumbar lesions have the best prognosis with the least deformity at presentation.

Behavior of Kyphosis in Adults

After the patient is put on chemotherapy, the kyphosis, if present, continues to grow despite being treated. This progression of kyphosis can be minimized by prescribing suitable braces. Patients treated nonoperatively have an average increase of 15 degrees in deformity.’Three to five per cent end up with a deformity greater than 60 degrees.

If operated with surgical decompression and bone grafting, still the kyphosis may grow as the bone graft is most weak on the day it is implanted. Furthermore,  graft slippage and breakage will give rise to progression of kyphosis.

Once the osseous fusion has occurred, the kyphosis does not grow at alarming rate in later life.

A lesion that heals with fibrous or fibro-osseous healing it may progresses further.

Behavior of Kyphosis in Children

Due to cartilaginous nature of vertebral bodies, the tubercular spine lesion causes more destruction. The kyphosis continues to increase with growth. The anterior growth potential of the vertebral body is either and unabated posterior growth may contribute to increase in the kyphotic deformity.

During growth spurt in a child

• 44% cases show improvement in kyphosis
• 17% show no changes in kyphotic angle
• 39% cases show progression of kyphosis
  • 10% will have exponential progression of kyphosis to > 90°.
  • The risk factors for exponential increase are
    • Age less than seven years at the time of disease
    • Thoracolumbar involvement
    • Loss of more than two vertebral bodies
    • Presence of two or more spine at risk signs.
  • Need strict observation and preventive surgery

Sequelae of Severe Kyphosis

In long term kyphosis affects the biomechanics of the spine and body.

• The proximal and distal segments of the spine compensate by creating reverse deformity
• Degenerative changes occur
  • Back pain
• > 60° kyphosis
  • Spinal cord changes occur due to repeated
  • May develop clinical signs of upper motor neuron deficit
• Compensatory hyperlordosis proximally and distal to healed lesion in lumbodorsal region.
• Severe lumbar canal stenosis in prolonged follow up
• Reduction in capacity of chest cavity and vital capacity
• Ventilatory failure
• Painful impingement of costal margins over iliac crest

Treatment of Kyphotic Deformity in Spinal Tuberculosis

Early diagnosis and treatment, preventive surgeries in patients who are likely to develop kyphosis and correction of angular kyphosis are mainstays of treatment.

Prevention of Deformity

If tubercular spine could be diagnosed in predestructive stage of disease  and treated with chemotherapy, it may with no sequelae of kyphosis.

In patients who present late, the progression of kyphosis depends on number of vertebral involvement, initial vertebral body loss and segment of spine affected.

The kyphosis continue to increase on non-operative treatment and even after surgical decompression.

The radiological signs of spine at risk are [These cases should undergo kyphosis correction.]

• Subluxation or dislocation of the facet joint at the apex of the kyphus
• Presence of retropulsion
• Translation of the vertebral column in coronal plane
• Posterior toppling sign
  • A line drawn along the anterior border of the distal healthy vertebra in an upward direction
  • If that meets the upper half of proximal healthy vertebra then it has chances of progressive kyphosis.

Kyphosis correction in active disease

All kyphosis cases which report for the first time with moderate to severe kyphosis of 50° of more, may be taken up for kyphosis correction surgery.

MEthods of kyphosis correction

• Single stage transpedicular approach.
  • Anterior decompression by posterior midline exposure through the pedicle of apex vertebra
  • Posterior stabilization with two vertebrae on each side of dorsal spine and one in lumbar spine.
• Single or two-staged anterior decompression with bone grafting followed by correction of kyphosis and posterior instrumentation
• Single stage kyphosis correction by extra pleural anterolateral approach.

Kyphosis correction in healed lesion

hazard of deformity correction outweighs the gain hence it should not be carried out for cosmetic reasons only.

The the patient should be warned about the risk of neural deterioration and life risk.

Corrective surgery for established de­formity is difficult, has to be staged, and also is hazardous with a high complication rate. There also is a constant danger of paraplegia because of the need for meticulous debridement of the tissues all around the spinal cord before osteotomy.  The patient must have prolonged postoperative immobilization in a halo-pelvic apparatus and a body cast until consolidation occurs.

References

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