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Intrathecal Pain Pump Concept, Use and Risks

By Dr Arun Pal Singh

In this article
    • Trial of Intrathecal Pumps
    • Intrathecal Pain Pump Placement
    • Medications
    • Complications of Intrathecal Pain Pump
      • Bleeding
      • Catheter Issues
      • Neurologic injury
      • Inflammatory mass
      • Other complications
      • Related

An intrathecal pain pump is a surgically implanted drug delivery system that sends pain medication directly to the spinal cord. This unique treatment option may be recommended to selected patients of chronic pain who have not experienced adequate pain relief from conservative approaches.

The intrathecal pain pump is a small battery-powered, programmable pump which is implanted under the subcutaneous tissue of the abdomen and connected to a small catheter to deliver small doses of medication directly to the spinal fluid. The pump needs to be refilled at a regular interval usually every 1 to 3 months.

The first clinical use of an implantable intrathecal drug delivery device was in 1981 in chronic pain of malignancy.

Though the efficacy of intrathecal pain pump has been repeatedly demonstrated, the adequate evidence is still missing and there is a lack of randomized studies.

There is also a concern of tolerance and drug addiction which is feared to occur with their use.

intrathecal pain pump

Therefore it cannot be used in all the patients of chronic pain. It is used in patients with advanced malignancies and selected patients with chronic non-malignant pain, especially where the oral opioids are required in larger doses which might risk the side-effects.

Prerequisites for use of intrathecal pain pump are

  • Failure of conservative therapies
  • Surgery is not considered or cannot be done
  • No active or untreated addiction
  • Medical contraindications like coagulopathies, infections
  • Successful trial s been completed.

Trial of Intrathecal Pumps

No intrathecal device should be implanted without first performing a trial [The trial is of the drug and the route for confirming the efficacy and not the implant itself]

The trial involves the infusion of the drug through an indwelling intrathecal or epidural catheter.

The drugs used are hydromorphone of 0.3mg/d or morphine sulfate 0.2 mg/d and the trial is done for 2-3 days.

A successful trial means a 50% improvement in pain score and improvement in function.

Intrathecal Pain Pump Placement

Under proper anesthesia and surgical precautions, a small incision is made posterior midline,  approximately 2-3 inches from the skin to the supraspinous fascia at approximately L2-3 or 3-4. The catheter is inserted into the intrathecal space. Another incision is made in the abdomen to place the pump between the skin and muscle in the right or left lower quadrant of the abdomen at or about the umbilical level.

The positioning of the catheter is checked with fluoroscopy.

After the procedure, the pump is programmed to deliver the prescribed amount of medication.

The patient is monitored after the procedure and discharged with aftercare instructions. These involve, amongst other to avoid strenuous, physical activity for 6-8 to eight weeks.

Driving and housework are not to be done for two to four weeks.

Medications

Opioids are mainly used drugs in the pain pumps. Other drugs include local anesthetics, adrenergic agonists, and other agents

The first line of treatment includes morphine or hydromorphone.

Morphine [15 mg/d], Hydromophone [10 mg/d], Bupivacaine [2-30 mg/d], Clonidine [10-1000 mg/d] are the usual doses used.

Complications of Intrathecal Pain Pump

Bleeding

  • Intra-operative bleeding
    • Ineffective local hemostasis
    • Overlooked ongoing anticoagulant therapy
    • spinal tumors which can be sources of bleeding during surgery.
  • Epidural hematoma
    • Due to persistent bleeding
    • Rapidly increasing back pain
    • Progresses to neurological deficits
  • Post-operative superficial bleeding
  • Seroma or hematoma can appear at the pump site

Catheter Issues

  • Kinking
  • Breakage
  • Leakage

Neurologic injury

  • During catheter placement
  • Inflammation of the catheter tip
  • Risk increases in presence of canal stenosis, arachnoiditis, or other intraspinal abnormalities

Inflammatory mass

  • Expanding sterile mass or granuloma at the tip of the catheter.
  • Presents
    • as new or increasing pain that worsens despite escalating doses of intrathecal opioids
    • New neurologic symptoms arise.
  • MRI confirms mass
  • Possibly due to the use of high concentrations of opioid, morphine specifically
  • If no neurologic deficits
    • Keep medication with preservative-free saline at a minimum pump rate
    • Serial MRIs to observe the regression
    • Restart a non-offending opioid when resolved
  • If neurologic deficits are present
    • Spinal cord decompression, mass removal, and catheter removal

Other complications

  • Infection
  • CSF leaks
  • Seroma formation around the pump pocket
  • Endocrinal change
    • Hypogonadotropic Hypogonadism.
    • Central hypocortisolism.
    • Decreased libido

Related

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Filed Under: Pain Management

About Dr Arun Pal Singh

Arun Pal Singh is an orthopedic and trauma surgeon, founder and chief editor of this website. He works in Kanwar Bone and Spine Clinic, Dasuya, Hoshiarpur, Punjab.

This website is an effort to educate and support people and medical personnel on orthopedic issues and musculoskeletal health.

You can follow him on Facebook, Linkedin and Twitter

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