Patterns of Bone Destruction

Different patterns of bone destruction as observed on x-rays are caused by a variety of disease process affecting the bone. Type of destruction suggests the intensity and aggression of the disease process. The role of radiographs in the diagnosis of the disease was much more before the advent of CT and MRI.

Due to more sensitivity of modern imaging, x-rays have a lesser role and are relatively insensitive in outlining early changes. The destruction patterns of bone we are about to discuss is described on x-ray images.

Three radiographic patterns of bone destruction have been identified –

• Geographic Bone Destruction
• Moth-eaten Appearance
• Permeative Bone Destruction

Patterns of Bone destruction are able to provide the information on bony involvement and how aggressively the disease is spreading and how effectively the host bone is able to repair or contain the bony lesion.

Musculoskeletal lesions typically occur within any given age range. Therefore and age of the patient must be considered when the lesions are evaluated.

Why do patterns of bone destruction differ?

Bone destruction and new bone formation are mediated by osteoclasts and osteoblasts.

Therefore, bony destruction seen on radiographs is a summation of osteoclasts resorptive activity on both the cortical and trabecular bone surfaces. The relative predominance of bone process over the other will be perceived as a visible margin to the lesion on the radiograph.

Destruction of cortical bone although slower is appreciated more easily because of the great contrast in density created by a local area of lysis as compared to cancellous bone where a large amount of trabecular bone must be removed before the loss will be evident on plain radiographs.

For this reason, lesions arising in cancellous bone may go undetected for long periods of time.

In order to reach a consistent grading conclusion, the following specific sign must be considered in this order of priority:

1. The pattern of bone destruction and the configuration of the marginal interface zone of the lesion.
2. Penetration of bone cortex by the lesion.
3. The presence or absence of a sclerotic rim.
4. The presence and extent of an expanded cortical shell.

Geographic Bone Destruction

The geographic pattern of bone destruction is the least aggressive pattern of bone destruction and is generally indicative of a slowly growing lesion. The margin of the lesion is well-defined and easily separated from the surrounding normal bone.

This margin may be smooth or irregular, but in either instance, it is usually clearly demarcated, with a short zone of transition from normal to abnormal bone.

In some instance, a sclerotic margin of variable thickness surrounds the lesion. The thicker and more complete the sclerotic margin, the less aggressive the process.

This type of destruction is seen as a well-circumscribed hole in the bone with a narrow zone transition between normal and abnormal bone. The pattern implies a slow growth rate, one that permits time for destruction of all bone in the path of the enlarging lesion. The geographic destruction patterns can be further divided into three subtypes.

• A—Geographic lesions with sclerotic margin:
• B—Geographic lesions without sclerotic margins:
• C—Geographic lesions with ill-defined margins.

The relative biological aggressiveness increases from type A to type C.

Geographic lesions with marginal sclerosis (type IA)

This pattern is most commonly associated with benign, slow-growing disorders. Lesions commonly falling into this category are unicameral bone cyst, non—ossifying fibroma enchondroma, chondromyxoid fibroma, chondroblastoma, and fibrous dysplasia. Sclerotic rims that gradually fade into the adjacent cancellous bone are commonly seen with chronic osteomyelitis, Brodie’s abscess, and histiocytosis X.

Geographic lesions with no sclerosis in the margin (type IB)

These lesions have sharply defined edges but not sclerotic margins. Normal trabeculae are present up to the edge of the lesion but totally removed along a plane of contact between the tumor and normal bone.

The lesions mentioned in IA category may also fall in this category when they demonstrate a more aggressive behavior. Giant cell tumors typically have IB margins.

Geographic lesions with ill-defined margins (type IC)

This type of geographic lesion is not only focally destructive but also locally infiltrative the disease spreads more than visible lytic lesion]. This creates a wider zone of transition at the margin of the lesion which reflects the greater biological. The lesion is less well-defined. Vigorous destruction of the cortex will result in complete perforation of the bone.

A soft tissue mass when present, indicates complete cortical penetration. Typical lesions with this pattern include giant cell tumor, fibrosarcoma, and chondrosarcoma. Aggressive form enchondroma, chondroblastoma, and desmoplastic fibroma can occasionally be classified in this category.

Moth-Eaten Bone Destruction

The moth-eaten pattern is a more aggressive pattern of bone destruction and is characteristic of a lesion that is growing more rapidly than one that demonstrates geographic bone destruction. The moth-eaten pattern is associated with a less well-defined or demarcated lesion margin and with a longer zone of transition from normal to the abnormal bone.

The moth-eaten appearance of the bone consists of multiple scattered holes that vary in size and seem to arise separately. These scattered holes coalesce to form larger areas of bone destruction.

In cancellous bone, normal trabecular markings can be seen between the holes because of the regionally infiltrative nature of this pattern.

Total penetration of the cortex is assumed with the moth-eaten pattern.

The moth-eaten pattern is frequently seen with malignant neoplasms such as Ewing’s sarcoma primary lymphoma of bone, chondrosarcoma, fibrosarcoma, and osteosarcoma. The aggressive form of osteomyelitis can also destroy bone with a moth-eaten pattern.

Some benign processes, such as eosinophilic granuloma, may be associated with moth-eaten destruction.

Permeative Bone Destruction

The permeative pattern indicates an aggressive bone lesion with rapid growth potential. The lesion is poorly demarcated and not easily separated from the surrounding normal bone. In fact, it may imperceptibly merge with uninvolved osseous segments and create a zone of transition that is very long.

Its true size is larger than that evident on radiographs.

The permeative pattern is characterized by numerous elongated holes or slots in the cortex that run parallel to the long axis of the bone. They are reasonably uniform in size. The slots are created by osteoclastic cortical tunneling in an accelerated caricature of the resorption phase of normal Haversian remodeling. Total penetration of the cortex is assumed with the permeative pattern.

Permeative destruction may be seen in several disease categories including neoplastic, mechanical inflammatory, and metabolic.

Tunneling may or maybe not be accompanied by tumor or inflammatory infiltrates.

Malignant lesion demonstrating this pattern tend to infiltrate the marrow space diffusely and include primary round cell tumors, fibrosarcoma, high-grade chondrosarcoma, and angiosarcoma.

An occasional benign process such a osteomyelitis will also show this patterns.

The pattern may be often difficult to differentiate from the permeative patterns of destruction.

Combination of Patterns of Bone Destruction

Any combination of geographic, ‘moth-eaten’, and permeative patterns in a single lesion is indicative of a change towards a more aggressive local growth. Combination patterns may be seen when benign lesions become more active, undergo malignant degeneration, or fracture. The development of a combination or a changing pattern can be documented by observing a sequence of radiographs.

Further Imaging of the Lesions

Further work-up, wherever required consists of MRI and/or CT

While CT is very good for bony evaluation of the lesion, MRI will also aid in establishing which compartments and structures are involved.

A nuclear medicine bone scan is performed to look for a multiple bone involvement.

If the lesion is still nonspecific after thorough imaging, image-guided biopsy of the lesion can be performed.

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